Areas of Research

• Immunology of Herpes Simplex keratitis
• Pathogenesis of endophthalmitis caused by Bacillus, Klebsiella and other bacterial pathogens
• Role of diabetes in systemic-to-ocular spread of infection
• Improved therapies for anterior and posterior segment bacterial infections
• Evolution of multidrug resistance in ocular bacterial infections
• Molecular pathogenesis of Toxoplasma ocular infections
• Role of CAP37 in inflammation during bacterial keratitis
• Role of CAP37 in pathogenesis of Alzheimers Disease

Retinal Cell Biology

• Post-translational modifications in rhodopsin
• Apoptosis in retinal degenerative disorders
• Biology of retinal light damage
• Role of DHA in normal retinal function
• Regulation of pathological neovascularization and neural differentiation
• Retinal degeneration and mutations in peripherin/rds
• Characterization of the cone CNG channel
• Molecular mechanisms of visual excitation
• Role of protein phosphorylation in neuronal function
• Molecular biology of cellular regulation in neurons
• Inhibition of retinal degeneration by nanoparticles
• Roles of arrestin and transducin in responses to light
• Novel therapies for genetic retinal diseases
• Mechanism of visual loss associated with rhodopsin mutations
• Sphingolipid metabolism in the retina
• Roles of photoreceptor retinol dehydrogenases in retinal dystrophy
• Mechanisms and therapeutics of macular degeneration
• Mechanisms of ocular growth, hyperopia, and myopia
• Role of insulin receptors in the retina
• Signaling mechanisms regulating plasticity of retinal synapses and circuits
• Role of circadian rhythm disruption in retinal degeneration